pentobarbital will minimize the extent or impact of trazodone by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Watch.
pentobarbital will lessen the level or influence of repaglinide by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.
Monitor Intently (one)pentobarbital will reduce the extent or outcome of levamlodipine by affecting hepatic/intestinal enzyme CYP3A4 metabolism.
pentobarbital improves levels of vortioxetine by escalating metabolism. Modify Therapy/Monitor Carefully. Consider raising the vortioxetine dose when coadministered with powerful CYP inducers for >fourteen days; to not exceed three instances primary vortioxetine dose.
If this drug is utilized throughout pregnancy, or if the affected individual gets to be Expecting although taking this drug, the affected individual really should be apprised from the potential hazard to your fetus
Reserve concomitant prescribing of these drugs in individuals for whom other remedy possibilities are inadequate. Restrict dosages and durations to the least needed. Watch intently for signs of respiratory depression and sedation.
pentobarbital will lower the extent or result of voriconazole by influencing hepatic enzyme CYP2C9/10 metabolism. Insignificant/Significance Mysterious.
pentobarbital will lower read more the extent or outcome of montelukast by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Minor/Significance Unfamiliar.
pentobarbital decreases amounts of ponatinib by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Avoid or Use Alternate Drug. Keep away from Except the coadministration outweighs the feasible possibility of ponatinib underexposure; watch for indications of reduced efficacy.
With therapeutic doses of TCAs, barbiturates improve metabolism and decrease blood concentrations of TCAs.
pentobarbital will lower the extent or impact of alfentanil by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Insignificant/Significance Unfamiliar.
Soon after halting a CYP3A4 inducer, since the effects on the inducer decrease, the fentanyl plasma concentration will boost which could boost or extend the two the therapeutic and adverse effects.
pentobarbital will decrease the level or influence of pioglitazone by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Minor/Significance Unidentified.
pentobarbital will lower the extent or impact of isavuconazonium sulfate by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated.